A synthetic phosphopeptide corresponding to residues surrounding Thr667 of human GCN2
Conjugation:
Unconjugated
Alternative Names:
GCN2-like protein, GCN2, KIAA1338, EIF2AK4
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
