Full length human recombinant protein of human GIPC1 (NP_974199) produced in E.coli.
Conjugation:
Unconjugated
Alternative Names:
PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein , RGS19-interacting protein 1, Synectin, Tax interaction protein 2 (TIP-2), GIPC1, C19orf3, GIPC, RGS19IP1
GIPC, for GAIP interacting protein at the C-terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for Ga i subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrincoated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.
The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB 1:500~2000, IHC 1:500
Application Notes:
IgG2a
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