KLH-conjugated synthetic peptide encompassing a sequence within human ALK5. The exact sequence is proprietary.
Conjugation:
Unconjugated
Alternative Names:
ALK5, SKR4, TGF-beta receptor type-1, TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, ALK5, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I
A total of three members of the TGFb family, namely TGFb1, TGFb2 and TGFb3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbs mediate their activity by high affinity binding to the TGFb receptor type-II (TGFb RII) with a cyto plasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses, TGFb RII requires both its kinase activity and its associ ation with a TGFb-binding protein, designated TGFb receptor type-1 (TGFb RI). TGFb RI is a 503 amino acid single-pass type I membrane protein that is expressed ubiquitously and, with TGFb RII, functions as a receptor for TGFb. Defects in the gene encoding TGFb RI are the cause of aortic aneurysm familial thoracic type 5 (AAT5), Loeys-Dietz syndrome type 2A (LDS2A) and Loeys-Dietz syndrome type 1A (LDS1A).
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Application Dilute:
IHC (1/100 - 1/300)
Application Notes:
Recognizes endogenous levels of ALK5 protein.
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