KLH-conjugated synthetic peptide encompassing a sequence within human TPSAB1. The exact sequence is proprietary.
Conjugation:
Unconjugated
Alternative Names:
TPS1, TPS2, TPSB1, Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1
Tryptase is the most abundant neutral serine protease expressed in the secretory granules of all human mast cells. Tryptase is secreted upon the coupled activation-degranulation response of mast cells in peripheral tissues to physical factors such as trauma, toxins, venoms, endogenous mediators, and immune mechanisms (IgE-dependent and IgE-independent). Tryptase has distinct enzymatic functions that depend on the monomeric or homotetrameric state of this protein, the pH of the environment, and the presence or absence of heparin. Tryptase has the ability to cleave extracellular substrates such as vasoactive intestinal peptides, calcitonin gene-related peptides, fibronectins, fibrinogens, and kininogens. Tryptase is also a potent growth factor for epithelial cells, airway smooth muscle cells, and fibroblasts.
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Application Dilute:
IHC (1/100 - 1/300)
Application Notes:
Recognizes endogenous levels of TPSAB1 protein.
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