KLH-conjugated synthetic peptide encompassing a sequence within human Villin. The exact sequence is proprietary.
Conjugation:
Unconjugated
Alternative Names:
VIL, Villin-1
Villin is a member of the gelsolin family of calcium-regulated actin-binding proteins. Unlike the ubiquitously expressed gelsolin, villin expression is restricted to simple epithelia of the gastrointestinal and urogenital tracts. It is localized to the apical cytoplasm and brush borders of these cells. Villin functions in the regulation of actin dynamics in the apical epithelium, capping, nucleating and/or severing actin filaments in a calcium-dependent manner and regulating cell shape in response to external stimuli. Phosphorylation of villin at Tyr60, 81, and 256 may be involved in the regulation of cell migration. Expression of villin is increased in colorectal cancers, and villin-1 function appears to be involved in progressive cholestasis and hepatic failure.
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Application Dilute:
WB (1/500 - 1/1000), IHC (1/100 - 1/300)
Application Notes:
Recognizes endogenous levels of Villin protein.
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