KLH-conjugated synthetic peptide encompassing a sequence within human Claudin 7. The exact sequence is proprietary.
Conjugation:
Unconjugated
Alternative Names:
CEPTRL2, CPETRL2, Claudin-7, CLDN-7
The Claudin superfamily consists of many structurally related proteins in humans . These proteins are important structural and functional components of tight junctions in paracellular transport . Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues . Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule . Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands . Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions . mRNA studies indicate that Claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis . The gene encoding human Claudin-7 maps to chromosome 17p13 .
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Application Dilute:
WB (1/500 - 1/1000), IHC (1/100 - 1/300)
Application Notes:
Recognizes endogenous levels of Claudin 7 protein.
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