KLH-conjugated synthetic peptide encompassing a sequence within human CD105. The exact sequence is proprietary.
Conjugation:
Unconjugated
Alternative Names:
END, Endoglin, CD105
CD105/Endoglin is an auxiliary receptor for the TGF-beta receptor complex, functioning in related signaling pathways . CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated CD105/endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure . The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer .
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Application Dilute:
WB (1/500 - 1/1000), IHC (1/100 - 1/300)
Application Notes:
Recognizes endogenous levels of CD105 protein.
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