Caspase 8 Rabbit monoclonal antibody, Unconjugated

Product Overview

• Article Name: Caspase 8 Rabbit monoclonal antibody, Unconjugated
• Biozol Catalog Number: BWT-MB66324
• Supplier Catalog Number: MB66324
• Alternative Catalog Number: BWT-MB66324-50UL,BWT-MB66324-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Hamster
• Immunogen: A synthetic peptide of human Caspase-8
• Conjugation: Unconjugated
• Alternative Names: MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH

Product Description

Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.

Product Properties

• Molecular Weight: ~ 55 kDa
• UniProt: O89110
• Purity: The antibody was purified by immunogen affinity chromatography.
• Form: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Application Notes

• Application Dilute: WB (1/500 - 1/1000)
• Application Notes: Recognizes endogenous levels of Caspase 8 protein.