cGAS monoclonal antibody, Unconjugated, Mouse

Product Overview

• Article Name: cGAS monoclonal antibody, Unconjugated, Mouse
• Biozol Catalog Number: BWT-MB67150
• Supplier Catalog Number: MB67150
• Alternative Catalog Number: BWT-MB67150-50UL,BWT-MB67150-100UL
• Manufacturer: Bioworld Technology
• Host: Mouse
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human cGAS. The exact sequence is proprietary.
• Conjugation: Unconjugated
• Alternative Names: C6orf150, Cyclic GMP-AMP synthase, cGAMP synthase, cGAS, h-cGAS, Mab-21 domain-containing protein 1

Product Description

Cyclic GMP-AMP synthase (cGAS, MB21D1) is an antiviral enzyme that produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA. The cGAS protein acts as a cytosolic DNA sensor that binds DNA and produces the cGAMP second messenger from ATP and GTP. cGAMP binds to and activates STING, a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA. STING is ubiquitously expressed and found predominantly in the ER. Following activation, STING translocates with TBK1 to perinuclear endosomes. The TBK1 kinase phosphorylates and activates interferon regulatory factors (IRFs) and NF-kappaB, which leads to the induction of type I interferon and other immune response genes.

Product Properties

• Molecular Weight: ~ 64 kDa
• UniProt: Q8N884
• Purity: This antibody is purified through a protein G column.
• Form: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Application Notes

• Application Dilute: WB (1/500 - 1/1000)
• Application Notes: Recognizes endogenous levels of cGAS protein.