Pontin 52 monoclonal antibody, Unconjugated, Mouse

Product Overview

• Article Name: Pontin 52 monoclonal antibody, Unconjugated, Mouse
• Biozol Catalog Number: BWT-MB67257
• Supplier Catalog Number: MB67257
• Alternative Catalog Number: BWT-MB67257-50UL,BWT-MB67257-100UL
• Manufacturer: Bioworld Technology
• Host: Mouse
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Immunogen: Recombinant fusion protein of human Pontin 52. The exact sequence is proprietary.
• Conjugation: Unconjugated
• Alternative Names: INO80H, NMP238, TIP49, TIP49A, RuvB-like 1, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, INO80 complex subunit H, Nuclear matrix protein 238, NMP 238, Pontin 52, TIP49a, TIP60-associated protein 54-alpha, TAP54-alpha

Product Description

Reptin/RuvBL2 and Pontin/RuvBL1 are closely related members of the AAA+ (ATPase associated with diverse cellular activities) superfamily of proteins, and are putatively homologous to bacterial RuvB proteins that drive branch migration of Holliday junctions. Reptin and Pontin function together as essential components of chromatin remodeling and modification complexes, such as INO80, TIP60, SRCAP, and Uri1, which play key roles in regulating gene transcription. In their capacity as essential transcriptional co-regulators, Reptin and Pontin have both been implicated in oncogenic transformations, including those driven by c-Myc, beta-catenin, and E1A.

Product Properties

• Molecular Weight: ~ 50 kDa
• UniProt: Q9Y265
• Purity: This antibody is purified through a protein G column.
• Form: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Application Notes

• Application Dilute: WB (1/500 - 1/1000)
• Application Notes: Recognizes endogenous levels of Pontin 52 protein.