Signal-regulatory protein gamma, SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-b2, SIRP-beta-2, CD172g, SIRPG, SIRPB2
SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain containing protein-tyrosine phosphatase SHP-2 in response to Insulin. The SIRP family negatively regulates the PI 3-K pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transforma tion of certain cell types. SIRP-alpha1 is a transmembrane protein which contains an extracellular portion with three immunoglobulin-like structures and a cyto plasmic region with four potential tyrosine phosphorylation sites. SIRP-alpha1 is a substrate for activated receptor tyrosine kinases. In its tyrosine phosphoryl ated form, SIRP-alpha1 binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-alpha1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and insu lin. SIRP-b1 shares extensive sequence homology with SIRP-alpha1 in its extra cellular portion but lacks the cytoplasmic portion. SIRP-g, originally designated SIRP-b2 (SIRP-B2, CD172g) has unique characteristics from both the alpha and b versions. SIRP-g is expressed on the majority of T cells and a proportion of B cells. CD47 associates with SIRP-g, and this interaction signals unidirec tionally only.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Application Dilute:
IF: 1:100~1:500
Application Notes:
CD172g polyclonal antibody detects endogenous levels of CD172g protein.
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