Recombinant Human Endothelial-MonocyteAActivating Polypeptide II (rHuEMAP-II)
Biozol Catalog Number:
BWT-PR1015
Supplier Catalog Number:
PR1015
Alternative Catalog Number:
BWT-PR1015-5UG,BWT-PR1015-20UG,BWT-PR1015-1.0MG
Manufacturer:
Bioworld Technology
Category:
Proteine/Peptide
EMAP-II is a tumor derived cytokine that exerts a wide range of activities on endothelial cells, monocytes and neutrophils. EMAP-II inhibits endothelial cell proliferation, vasculogenesis, neovessel formation, and can induce apoptosis. It is also chemotactic towards neutrophils and monocytes and induces myeloperoxidase activity from neutrophils. Of clinical importance, EMAP-II inhibits angiogenesis of vascular beds and suppresses the growth of primary and secondary tumors without affecting normal tissues. Mature EMAP-II is an 18.3 kDa protein, which is synthesized as the C-terminal portion of a biologically inactive precursor protein containing a propeptide of 146 amino acid residues.
Molecular Weight:
Approximately 18.3 KDa, a single non-glycosylated polypeptide chain containing 166 amino acids.
Source:
Escherichia coli.
Purity:
>98% by SDS-PAGE and HPLC analyses.
Form:
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a 0.2mm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.
Application Notes:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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