Recombinant Human Interleukin-1 beta (rHu IL-1beta)
Biozol Catalog Number:
BWT-PR1055
Supplier Catalog Number:
PR1055
Alternative Catalog Number:
BWT-PR1055-2UG,BWT-PR1055-10UG,BWT-PR1055-1.0MG
Manufacturer:
Bioworld Technology
Category:
Proteine/Peptide
IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.
Molecular Weight:
Approximately 17.3 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.
Source:
Escherichia coli
Purity:
>97% by SDS-PAGE and HPLC analyses.
Form:
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.5.
Application Notes:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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