Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows an approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include: induction of secretion of interferon-gamma and tumor necrosis factors -alpha and -beta from peripheral blood mononuclear cells stimulation of the rate of synthesis of c-myc RNA and transferrin receptor activation of neutrophils stimulation of proliferation and maturation of activated helper T cells stimulation of proliferation of activated and natural killer cells and tumor-infiltrating lymphocytes, as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells induction of the expression of IL-2 receptors on T cells stimulation of proliferation of antibody-producing B cells
Molecular Weight:
Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids.
Source:
Escherichia coli.
Purity:
>97% by SDS-PAGE and HPLC analyses.
Form:
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.5.
Application Notes:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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