Lipid A9 is an ionizable cationic lipid (pKa = 6.27) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vivo. LNPs containing lipid A9 and encapsulating non-stimulatory siRNA increase plasma levels of chemokine (C-C motif) ligand 2 (CCL2), indicating activation of the innate immune response, and decrease body weight in mice.
Molecular Weight:
905.51
Purity:
>95%
CAS Number:
[2036272-50-9]
Formula:
C57H112N2O5
Chemical structure of orb1146695
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