Human anti-SARS-CoV & CoV-2 NP antibody recognize human SARS Coronavirus Nucleocapsid protein (NP). Coronavirus NP localize to the cytoplasm and the nucleolus in both Virus-like particle (VLP) infected primary cells and in cells transfected with NP plasmid. NP has abundant expression in coronavirus and is a highly immunogenic phosphoprotein. NP is also conserved in sequence. Due to these characteristic above, the NP is an ideal marker for diagnosis.
