Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.Hoechst 34580 is a good candidate for treating Alzheimers disease by inhibiting Abeta formation. 50 µM Abeta42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 µM Hoechst 34580 at 37 C for 70 h. Hoechst 34580 can inhibit the aggregation of Abeta42 in a dose-dependent manner.
Molecular Weight:
451.6
Purity:
>98% (HPLC)
CAS Number:
[23555-00-2]
Formula:
C27H29N7
Target:
Amyloid-beta
Chemical structure of Hoechst 34580
Chemical structure of Hoechst 34580
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