HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for various NHE isoforms.
Molecular Weight:
311.8
Purity:
>98% (HPLC)
CAS Number:
[1428-95-1]
Formula:
C12H18ClN7O
Target:
NHE exchangers| TRPA1| ASIC3| P2X7
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