Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis.
Molecular Weight:
386.4
Purity:
>98% (HPLC)
CAS Number:
[73069-27-9]
Formula:
C21H22O7
Target:
CAM
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