MRTX1133, CAS [[2621928-55-8]]

Product Overview

• Article Name: MRTX1133, CAS [[2621928-55-8]]
• Biozol Catalog Number: BYT-ORB1298201
• Supplier Catalog Number: orb1298201
• Alternative Catalog Number: BYT-ORB1298201-1, BYT-ORB1298201-5, BYT-ORB1298201-1, BYT-ORB1298201-10, BYT-ORB1298201-25, BYT-ORB1298201-50, BYT-ORB1298201-100
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: active, cells, Inhibitor, ERK, G12D, mutant, MRTX1133, MRTX-1133, MRTX 1133, inactive, KRAS G12D, KRAS, inhibit, tumor, states, Ras, phosphorylation, wild-type

Product Description

MRTX1133 is a potent, selective, and non-covalent small-molecule inhibitor targeting the KRAS G12D mutant with sub-picomolar affinity (K_D = 0.2 pM). It demonstrates antitumor efficacy in G12D-mutated cell lines and in vivo models, showing selectivity over wild-type KRAS, making it a valuable research tool for oncology and targeted therapy studies.

Product Properties

• Molecular Weight: 600.63
• Purity: 99.60% (May vary between batches)
• CAS Number: [2621928-55-8]
• Formula: C33H31F3N6O2
• Target: Kras,Ras

Application Notes

• Application Notes: Solubility: DMSO: 50 mg/mL (83.25 mM), Sonication is recommended