NEO2734, NEO-2734, NEO 2734, inhibit, MYC, Inhibitor, HAT, HATs, Histone Acetyltransferase, HistoneAcetyltransferase, Epigenetic Reader Domain, EpigeneticReaderDomain, EP 31670, EP31670, EP-31670, CBP, BET bromodomain, SPOP, TC-797, p300, p300/CBP, PER-403
NEO2734 is a potent dual inhibitor of the p300/CBP and BET bromodomain families, exhibiting IC50 values below 30 nM for both targets. This orally bioavailable small molecule is a valuable chemical probe for epigenetic research in oncology, enabling mechanistic studies in both cellular and animal models of cancer.