Apcin, CAS [[300815-04-7]]

Product Overview

• Article Name: Apcin, CAS [[300815-04-7]]
• Biozol Catalog Number: BYT-ORB1298832
• Supplier Catalog Number: orb1298832
• Alternative Catalog Number: BYT-ORB1298832-1, BYT-ORB1298832-1, BYT-ORB1298832-10, BYT-ORB1298832-100, BYT-ORB1298832-2, BYT-ORB1298832-25, BYT-ORB1298832-5, BYT-ORB1298832-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: mitosis, inhibit, ligase, Inhibitor, cyclosome, complex, Cdc20, Apcin, APC/C, APC, anaphase-promoting, Anaphase promoting complex, pocket, recognition, WD40-domain, ubiquitylation

Product Description

Apcin is a potent, competitive inhibitor of the APC/C-Cdc20 E3 ligase, binding Cdc20 to block substrate recognition and ubiquitination. This inhibition arrests cells in mitosis and is synergistically enhanced by Ts-Arg-OMe, making it a valuable tool for studying cell cycle regulation, mitotic exit, and aneuploidy in both cellular and biochemical assays.

Product Properties

• Molecular Weight: 438.65
• Purity: 96.74% (May vary between batches)
• CAS Number: [300815-04-7]
• Formula: C13H14Cl3N7O4
• Target: APC/C

Application Notes

• Application Notes: Solubility: DMSO:235 mg/mL (535.73 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.4 mM)