WZ-3146, CAS [[1214265-56-1]]

Product Overview

• Article Name: WZ-3146, CAS [[1214265-56-1]]
• Biozol Catalog Number: BYT-ORB1300517
• Supplier Catalog Number: orb1300517
• Alternative Catalog Number: BYT-ORB1300517-1,BYT-ORB1300517-2,BYT-ORB1300517-5,BYT-ORB1300517-10,BYT-ORB1300517-25,BYT-ORB1300517-50,BYT-ORB1300517-100
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: inhibit, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (E746_A750), EGFR (E746_A750/T790M), ErbB-1, Epidermal growth factor receptor, HER1, Inhibitor, WZ3146, WZ-3146, WZ 3146

Product Description

WZ3146 is a potent, mutant-selective irreversible inhibitor targeting EGFR(L858R) and EGFR(E746_A750) with IC50 values of 2 nM each, while sparing ERBB2 phosphorylation (T798I). It is a valuable chemical probe for studying oncogenic EGFR signaling in both cellular and animal models of non-small cell lung cancer.

Product Properties

• Molecular Weight: 464.95
• Purity: 98.95% (May vary between batches)
• CAS Number: [1214265-56-1]
• Formula: C24H25ClN6O2
• Target: EGFR

Application Notes

• Application Notes: Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM),Ethanol:< 1 mg/mL (insoluble or slightly soluble),DMSO:86 mg/mL (184.97 mM),H2O:< 1 mg/mL (insoluble or slightly soluble)