Desmethyl Erlotinib hydrochloride, CAS [[183320-51-6]]
Catalog Number:
BYT-ORB1300610
Product Overview
Article Name:
Desmethyl Erlotinib hydrochloride, CAS [[183320-51-6]]
Biozol Catalog Number:
BYT-ORB1300610
Supplier Catalog Number:
orb1300610
Alternative Catalog Number:
BYT-ORB1300610-1,BYT-ORB1300610-10,BYT-ORB1300610-100,BYT-ORB1300610-2,BYT-ORB1300610-25,BYT-ORB1300610-5,BYT-ORB1300610-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
Alternative Names:
CP 473420, CP 373420, CP-373420, CP373420, CP-473420, CP473420, DesMethyl Erlotinib (CP-473420) HCl, Desmethyl Erlotinib hydrochloride, Desmethyl Erlotinib Hydrochloride, Desmethyl Erlotinib, Drug Metabolite, DrugMetabolite, inhibit, OSI420, OSI-420, OSI 420, EGFR, Inhibitor
Product Description
Desmethyl Erlotinib hydrochloride (OSI-420) is the pharmacologically active metabolite of the EGFR inhibitor erlotinib. It potently inhibits EGFR tyrosine kinase activity and its autophosphorylation, with IC50 values of 2 nM and 20 nM, respectively. This compound is widely used in cancer research for in vitro mechanistic studies and in vivo models of EGFR-driven tumors.
Product Properties
Molecular Weight:
415.87
Purity:
99.49% (May vary between batches)
CAS Number:
[183320-51-6]
Formula:
C21H21N3O4HCl
Target:
EGFR,Drug Metabolite
Application Notes
Application Notes:
Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.81 mM),DMSO:77 mg/mL (185.15 mM),Ethanol:< 1 mg/mL (insoluble or slightly soluble)
