GW 506U78, HSB-2, MOLT-4, Nelzarabine, Nelarabine, P12, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, Nucleoside Antimetabolite, JURKAT, inhibit, Inhibitor, DND41, DNASynthesis, DNA Synthesis, DNA synthesis (ALL-SIL cells), DNA synthesis (HSB2 cells), DNA synthesis (JURKAT cells), DNA synthesis (PER-255 cells), 506U78, acute lymphoblastic leukaemia, Analog, Apoptosis, T-ALL, RNASynthesis, RNA Synthesis
Nelarabine (GW 506U78) is a purine nucleoside analog that inhibits DNA synthesis, demonstrating potent antitumor activity with IC50 values ranging from 0.067 to 2.15 µM in cellular assays. It is widely used in research for studying T-cell acute lymphoblastic leukemia (T-ALL) and has been evaluated in both in vitro and in vivo experimental models.
