Indoximod (NLG-8189) is a methylated tryptophan analog that acts as an immune checkpoint inhibitor by targeting indoleamine 2,3-dioxygenase (IDO). Its inhibition of IDO prevents tryptophan depletion, thereby countering T-cell anergy and immunosuppression. This small molecule is utilized in both in vitro and in vivo research to study cancer immunotherapy, autoimmune diseases, and T-cell function.
Molecular Weight:
218.25
Purity:
99.55% (May vary between batches)
CAS Number:
[110117-83-4]
Formula:
C12H14N2O2
Target:
Indoleamine 2,3-Dioxygenase (IDO),IDO
Application Notes:
Solubility: DMSO:Slightly soluble
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