PHA-767491 is a potent, ATP-competitive dual inhibitor of Cdc7 and CDK9 kinases, exhibiting IC50 values of 10 nM and 34 nM, respectively. It is widely used in biochemical and cellular research to investigate DNA replication stress, transcription, and oncology-related pathways in both in vitro and in vivo models.
Molecular Weight:
213.24
Purity:
>99.99% (May vary between batches)
CAS Number:
[845714-00-3]
Formula:
C12H11N3O
Target:
Cholecystokinin Receptor,CDK,GSK-3
Application Notes:
Solubility: DMSO:40 mg/mL (187.58 mM),H2O:< 1 mg/mL (insoluble or slightly soluble),Ethanol:< 1 mg/mL (insoluble or slightly soluble)
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