Semagacestat, CAS [[425386-60-3]]
Catalog Number:
BYT-ORB1301052
Product Overview
Article Name:
Semagacestat, CAS [[425386-60-3]]
Biozol Catalog Number:
BYT-ORB1301052
Supplier Catalog Number:
orb1301052
Alternative Catalog Number:
BYT-ORB1301052-2,BYT-ORB1301052-1,BYT-ORB1301052-5,BYT-ORB1301052-10,BYT-ORB1301052-25,BYT-ORB1301052-50,BYT-ORB1301052-100
Manufacturer:
Biorbyt
Category:
Biochemikalien
Alternative Names:
BetaAmyloid, Beta Amyloid, Amyloid-beta, bAmyloid, b Amyloid, Abeta, LY 450139, LY450139, LY-450139, inhibit, Inhibitor, Notch, Gammasecretase, Gamma secretase, Semagacestat, beta Amyloid, betaAmyloid, beta-amyloid peptide, gamma secretase(Abeta42), gamma secretase(Abeta38), gamma secretase(Abeta40), gamma-secretase
Product Description
Semagacestat (LY450139) is a potent gamma-secretase inhibitor that reduces Abeta peptide production (Abeta42/Abeta40/Abeta38) and inhibits Notch signaling with nanomolar IC50 values. It has been utilized in both in vitro and in vivo research models to investigate Alzheimers disease pathology and Notch-related cellular processes.
Product Properties
Molecular Weight:
361.44
Purity:
99.90% (May vary between batches)
CAS Number:
[425386-60-3]
Formula:
C19H27N3O4
Target:
Gamma-secretase,Beta Amyloid
Application Notes
Application Notes:
Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.92 mM),H2O:< 1 mg/mL (insoluble or slightly soluble),DMSO:67 mg/mL (185.37 mM),Ethanol:39 mg/mL (107.9 mM)
