YKL-5-124, CAS [[1957203-01-8]]

Product Overview

• Article Name: YKL-5-124, CAS [[1957203-01-8]]
• Biozol Catalog Number: BYT-ORB1305905
• Supplier Catalog Number: orb1305905
• Alternative Catalog Number: BYT-ORB1305905-1, BYT-ORB1305905-5, BYT-ORB1305905-1, BYT-ORB1305905-10, BYT-ORB1305905-25, BYT-ORB1305905-50, BYT-ORB1305905-100
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: Inhibitor, irreversible, inhibit, arrest, covalent, CDK, CDK7/Mat1/CycH, CDK7/Cyclin H/MAT1, CDK7, cell-cycle, Cyclin dependent kinase, YKL5124, YKL-5-124, YKL 5 124, Pol-II, T-loop, phosphorylation, transcription

Product Description

YKL-5-124 is a covalent, highly selective CDK7 inhibitor with an IC50 of 9.7 nM against the CDK7/Mat1/CycH complex, demonstrating over 130-fold selectivity versus CDK2 and CDK9. It is a valuable chemical probe for studying transcriptional regulation and cell cycle progression in cancer research models, both in vitro and in vivo.

Product Properties

• Molecular Weight: 515.61
• Purity: 99.50% (May vary between batches)
• CAS Number: [1957203-01-8]
• Formula: C28H33N7O3
• Target: CDK

Application Notes

• Application Notes: Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.7 mM),DMSO:220 mg/mL (426.68 mM)