GAP43 encoded by this gene has been termed a growth or plasticity protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene
Purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Form:
Supplied at 1.0mg/mL in phosphate-buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol
Sequence:
Peptide sequence around phosphorylation site of Ser41 (Q-A-S(p)-F-R) derived from Human GAP43
Target:
The antibody detects endogenous level of GAP43 only when phosphorylated at Ser41
Application Dilute:
Immunofluorescence: 1:100 - 1:200
Application Notes:
Modification: Phosphorylated
Confocal immunofluorescent analysis of Hela cells using GAP43(Phospho-Ser41) antibody
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