Application Notes: Detect Range: 62.5 pg/mL-4000 pg/mL. Sensitivity: 10 pg/mL. Gene_name: MICA. Gene_full_name: MHC class I polypeptide-related sequence A. Protein_name: MHC class I polypeptide-related sequence A. Sample Type: cell culture supernates cell lysates tissue homogenates and serum. Tmb_incubation: 15-20 min. Capture_antibody: monoclonal antibody from mouse. Detection_antibody: polyclonal antibody from goat. Research_category: immunology|adaptive immunity|mhc|class i|innate immunity|nk cells. Sequence_similarities: Belongs to the MHC class I family. MIC subfamily. Tissue_specificity: Widely expressed with the exception of thecentral nervous system where it is absent. Expressed predominantlyin gastric epithelium and also in monocytes keratinocytes endothelial cells fibroblasts and in the outer layer of Hassalscorpuscles within the medulla of normal thymus. In skin expressedmainly in the keratin layers basal cells ducts and follicles.Also expressed in many but not all epithelial tumors of lung breast kidney ovary prostate and colon. In thyomas overexpressed in cortical and medullar epithelial cells. Tumorsexpressing MICA display increased levels of gamma delta T-cells
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