inhibit, KcsA, Guanfu base A, Guan-fu base A, Inhibitor, hERG, CYP2D6, PotassiumChannel, Potassium Channel
Guanfu base A is a potent, noncompetitive inhibitor of the cytochrome P450 2D6 enzyme (CYP2D6) and also blocks the hERG potassium channel. This dual activity makes it a valuable pharmacological tool for investigating drug metabolism interactions and cardiac safety in both in vitro and in vivo research settings.