Flavopiridol, CAS [[146426-40-6]]

Product Overview

• Article Name: Flavopiridol, CAS [[146426-40-6]]
• Biozol Catalog Number: BYT-ORB1685546
• Supplier Catalog Number: orb1685546
• Alternative Catalog Number: BYT-ORB1685546-1, BYT-ORB1685546-10, BYT-ORB1685546-2, BYT-ORB1685546-25, BYT-ORB1685546-5
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: Alvocidib, Apoptosis, Autophagy, CDK6, CDK7, CDK4, CDK, CDK1, CDK2, Cyclin dependent kinase, HIV, HIV Protease, HIVProtease, HMR 1275, HMR1275, HMR-1275, L868275, L-868275, L86-8275, Inhibitor, Human immunodeficiency virus, Flavopiridol, inhibit, NSC 649890 HCl, L 868275

Product Description

Flavopiridol (Alvocidib) is a potent ATP-competitive inhibitor of cyclin-dependent kinases CDK1, CDK2, CDK4, and CDK6 (IC50 ~40 nM), demonstrating selectivity over CDK7. It has been investigated in preclinical and clinical studies (Phase 1/2) for oncology research, showing activity in both in vitro cell proliferation assays and in vivo tumor models.

Product Properties

• Molecular Weight: 401.84
• Purity: 99.99% (May vary between batches)
• CAS Number: [146426-40-6]
• Formula: C21H20ClNO5
• Target: Apoptosis,Autophagy,HIV Protease,CDK

Application Notes

• Application Notes: Solubility: DMSO:34 mg/mL (84.61 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.98 mM),Ethanol:8 mg/mL (19.91 mM),H2O:< 1 mg/mL (insoluble or slightly soluble)