CAY10753 is a potent and selective tankyrase 2 (TNKS2) inhibitor with an IC50 of 0.3 nM, showing selectivity over TNKS1, PARP1, and PARP2. It inhibits the proliferation of DLD-1 colorectal cancer cells at 1 µM, making it a useful chemical probe for studying Wnt/beta-catenin signaling in cancer research.
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