TAS05567 is a potent and highly selective ATP-competitive inhibitor of Syk with an IC50 of 0.37 nM. It demonstrates selectivity, showing significant activity against only four other kinases (FLT3, JAK2, KDR, RET) in a broad panel. This inhibitor is a valuable tool for investigating Syk-dependent signaling pathways in both in vitro and in vivo immunological and oncological research contexts.
Molecular Weight:
439.51
CAS Number:
[1429038-15-2]
Formula:
C21H29N9O2
Target:
c-RET,Syk,JAK,FLT
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