HIV-1 reverse transcriptase, HIVProtease, HIV-1, HIV Protease, AVX 754, AVX754, AVX-754, Apricitabine, DNA Synthesis, DNA polymerase alpha, DNA polymerase gamma, DNA polymerase beta, DNASynthesis, SPD 754, SPD754, SPD-754, RNA Synthesis, RNASynthesis
Apricitabine (SPD754) is the (-)-enantiomer of dOTC, a potent and selective oral HIV-1 reverse transcriptase inhibitor. It demonstrates significant antiviral activity in clinical studies with a favorable resistance profile and good tolerability in patients, while showing lower affinity for host DNA polymerases.
