GNE-987 is a potent chimeric BET degrader that binds with low nanomolar affinity to both BD1 and BD2 bromodomains of BRD4. It demonstrates picomolar cellular degradation activity and is a valuable chemical probe for oncology research, particularly in studying BET protein function in hematological cancers like AML, both in vitro and in vivo.
Molecular Weight:
1096.31
CAS Number:
[2417371-71-0]
Formula:
C56H67F2N9O8S2
Target:
Epigenetic Reader Domain
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