L-778123 is a dual inhibitor of farnesyltransferase (FPTase) and geranylgeranyltransferase-I (GGPTase-I), effectively blocking Ki-Ras prenylation. It has demonstrated radiosensitizing properties in patient-derived pancreatic cancer cell lines and, combined with radiotherapy, showed acceptable toxicity in clinical trials for locally advanced pancreatic cancer.
Molecular Weight:
478.802
CAS Number:
[183499-56-1]
Formula:
C22H22Cl3N5O
Target:
Transferase,Others
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