SHP2/CDK4-IN-1 is a potent, orally active dual inhibitor of SHP2 (IC50=4.3 nM) and CDK4 (IC50=18.2 nM). It induces cell cycle arrest and inhibits proliferation in TNBC cells, demonstrating significant in vivo antitumor efficacy in syngeneic mouse models, making it a valuable tool for triple-negative breast cancer research.
Molecular Weight:
693.21
CAS Number:
[2924036-87-1]
Formula:
C33H35ClF2N10OS
Target:
Phosphatase,CDK,Others
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