SLU-PP-332 is a pan-ERR agonist with high affinity for ERRalpha, ERRbeta, and ERRgamma (EC50: 98, 230, and 430 nM). In skeletal muscle cells, it enhances mitochondrial function, respiration, type IIa fiber formation, and exercise endurance. It shows promise for studying and treating metabolic diseases, muscle dysfunction, and age-related decline.