RMC-6291 is an orally active, covalent inhibitor of KRAS G12C (ON) that forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA), thereby preventing KRAS G12C (ON) from signaling via steric blockade of RAS effector binding and eliciting deep and durable suppression of RAS pathway activity in KRAS G12C tumor models.
Molecular Weight:
1012.26
Purity:
98.73%
CAS Number:
[2641998-63-0]
Formula:
C55H78FN9O8
Target:
ERK,Kras,Ras,Apoptosis
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