HTH-01-091 (TFA) is a potent, selective MELK inhibitor (IC50 = 10.5 nM) with additional activity against kinases including PIM1/2/3 and RIPK2. Its profile supports its use as a chemical probe in breast cancer research, facilitating studies on tumor cell proliferation and survival in both cellular and animal models.
Molecular Weight:
613.46
Formula:
C28H29Cl2F3N4O4
Target:
Others,mTOR,Pim,RIP kinase,GSK-3,DYRK,MELK,CDK
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