Prostaglandin J2 (PGJ2) is a potent DP receptor agonist derived from PGD2, with high affinity for hDP (Ki=0.9 nM) and hCRTH2 receptors. It induces cAMP production, oxidative stress, and neuronal apoptosis, making it a critical tool for studying neurotoxic mechanisms in Alzheimers and Parkinsons disease models in vitro.
