Cimiside E exhibits anti-inflammatory activity by selectively inhibiting TNF-alpha-induced VCAM-1 expression, an effect mediated through PPAR-gamma upregulation and involving ERK1/2, PI3K, and PKC signaling. It also demonstrates potential chemopreventive properties against gastric cancer by inducing cell cycle arrest and apoptosis in vitro.
Molecular Weight:
602.809
CAS Number:
[154822-57-8]
Formula:
C35H54O8
Target:
Caspase,PKC,Akt,PI3K,TNF,ROS,ERK,PPAR
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