2(3)-O-Anthraniloylguanosine-5-O-triphosphate (2-ANT-GTP) and 3-ANT-GTP are fluorescent derivatives of GTP that exhibit spontaneous isomerization. 2(3)-ANT-GTP features an emission peak at 428 nm when excited at 330 nm in aqueous conditions. It functions as an inhibitor of several adenylyl cyclases, notably mammalian adenylyl cyclase 1 (AC1, Ki = 10 nM with manganese), inhibits B. anthracis adenylyl cyclase toxin edema factor (Kis = 4.1 and 13 µM with manganese and magnesium, respectively), and B. pertussis adenylyl cyclase toxin CyaA (Ki = 29 µM with manganese).
Molecular Weight:
730.23
Formula:
C17H17N6O15P3.4Na
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