MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory concentrations (IC50) of 0.64 µM for MptpB, 4.06 µM for MptpA, and 4.14 µM for PTP1B. Despite its inhibition potency, MptpB-IN-2 demonstrates limited antituberculosis efficacy, with a minimum inhibitory concentration (MIC) of 64.9 µM against Mtb H37Rv.
Molecular Weight:
479.54
Formula:
C23H20F3NO3S2
Target:
Antibiotic
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