RORgamma antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORgamma with a dissociation constant (K D) of 0.18 µM. It demonstrates anti-proliferative effects in the HPAF-II pancreatic cancer xenograft model, inhibits the RAS/MAPK and AKT/mTORC1 signaling pathways, and triggers caspase-dependent apoptosis in pancreatic cancer cells.
Molecular Weight:
540.86
Formula:
C35H60N2O2
Target:
ROR
* VAT and and shipping costs not included. Errors and price changes excepted
