Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with IC50 values of 0.403 µM for HDAC1, 0.591 µM for HDAC2, 3.552 µM for HDAC3, and 0.459 µM for HDAC6. The compound induces G2 phase cell cycle arrest, promotes apoptosis, hampers hematoma and solid tumor cell proliferation, diminishes tumor metastasis, and inhibits tumor growth in a liver tumor allograft mouse model.
Molecular Weight:
382.38
Formula:
C21H19FN2O4
Target:
Others
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