COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2 and 15-LOX with inhibitory concentrations (IC50) of 0.075 µM and 1.97 µM, respectively. This compound effectively suppresses LPS-induced production of pro-inflammatory cytokines (IL-6, ROS, and NO), exhibiting targeted anti-inflammatory effects.
Molecular Weight:
465.54
Formula:
C25H24FN3O3S
Target:
Lipoxygenase
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