IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPARgamma), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the beta-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compounds ability to suppress tumor growth and metastasis.
Molecular Weight:
886.48
Formula:
C51H70BrClN4O2
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